Nigeria, Senegal, Ghana, and the holders Algeria started the group stage qualifiers with back-to-back victories.
Tunisia (1-0 winners in Equatorial Guinea), and Madagascar, who won 6-2 in Niger, added their names to that list with wins on the 19th November.
And the finals competition has now been moved back to January due to weather concerns during the Cameroon summer period.
The quarter-final draw includes a tie against Zamalek for the holders Esperance.
Matches will begin at the end of February.
Bayern Munich eased to a 3-0 away win at Chelsea on Tuesday night helped by a double from Serge Gnabry.
Barcelona secured a 1-1 draw in Napoli after Antoine Griezmann levelled for the Catalans.
While the following day Manchester City justified their favoured status by winning 2-1 at Real Madrid.
And OL overcame a lacklustre Juventus by a single goal at the Groupama Stadium.
Champions-elect Liverpool needed to recover from 2-1 down to beat West Ham at Anfield on Monday.
Sadio Mane got the winner for Jurgen Klopp's team who can secure that first title by winning their next four league games.
Lionel Messi managed just the four goals in Barca's 5-0 drubbing of Eibar at the Camp Nou.
While their great rivals Real Madrid went down 1-0 at Levante.
Juventus won 2-1 at SPAL with Cristiano Ronaldo again on the scoresheet.
And there was a bunch of postponements on Sunday but both Rome clubs managed victories with Lazio winning at Genoa to stay within a point of the lead.
With OM losing 3-1 at home to Nantes it leaves PSG well in control of Ligue 1.
The Parisians would edge Bordeaux 3-2 at the Parc helped by goals from Mbappe and Cavani.
Bayern Munich edged lowly Paderborn 3-2 at the Allianz Arena on Friday with Robert Lewandowski contributing a double.
But RB Leipzig, 5-0 winners at Schalke, and Borussia Dortmund, 2-0 in Bremen, stayed close behind the Bavarians.
Porto beat Portimonense 1-0 to keep up the pressure on Benfica.
But the Lisbon giants kept ahead thanks to a Carlos Vinicius goal at Gil Vicente on Monday night.
Scottish giants Rangers became the first team through to the Europa League Round of 16 after a 1-0 second leg win in Braga.