As the group stage starts Liverpool began their defence of the title by losing 2-0 at Napoli.
Tuesday's winners also included Valencia (at Chelsea), RB Leipzig, Red Bull Salzburg (6-2 over Genk), and Ajax.
While the heavyweight encounter between Borussia Dortmund and Barcelona ended goalless at Signal Iduna Park.
On Wednesday there were victories for PSG (who beat Real Madrid 3-0 in Paris), Dynamo Zagreb, Bayern Munich, Manchester City, and Lokomotiv Moscow.
And two teams fought back from two goals down to gain draws - Olympiacos against Spurs and Atletico Madrid at home to Juventus.
After mixed results in midweek Liverpool face a tricky visit to Chelsea while Manchester City look to have the easier assignment at home to lowly Watford.
The top game could be in Seville where Sevilla host Real Madrid (beaten in Europe during the week)
The weekend highlight in Italy should be at San Siro where leaders Inter play rivals AC Milan .
PSG travel south to meet OL on Sunday, the same day Rennes, in 2nd, entertain Lille, in 5th.
After drawing with the champions last weekend RB Leipzig visit Werder Bremen while joint-second Dortmund are also away - at Eintracht Frankfurt.
Will leaders Famalicao's bubble be burst at Sporting on Sunday?
AFRICAN PLAYER NEWS & GOSSIP
Asamoah Gyan (Ghana) moves to NorthEast United in India.
And Toni Conceicao (Portugal) is the new coach of the Cameroon national team.
Senegal remain the leading African nation as per the latest FIFA rankings table.
Tunisia are considered second best followed by Nigeria and Algeria.
UEFA Europa League favourites Manchester United beat Astana 1-0 at Old Trafford on Thursday while other winners included Arsenal (at Frankfurt), Braga, Porto, Sevilla, and Roma.